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Arq. bras. oftalmol ; 80(2): 69-73, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-838794

ABSTRACT

ABSTRACT Purpose: We aimed to compare the retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and the choroid thickness between patients with Behcet disease and healthy subjects by using spectral domain optical coherence tomography (SD-OCT). Methods: Ninety eyes of 45 healthy subjects and 104 eyes of 52 patients with Behcet disease were included in this study. Rheumatoid factor and C-reactive protein levels were measured by blood testing in the patients. Results: The mean thickness of the retinal nerve fiber layer, ganglion cells layer, and inner plexiform layer were significantly lower in patients with Behcet's disease than in the healthy subjects. The mean choroidal thickness was significantly higher in the patients than in the healthy subjects. Conclusions: SD-OCT was a useful and non-invasive tool for the detection of retinal nerve degeneration and choroidal changes in patients with Behcet disease even in the absence of ocular involvement.


RESUMO Objetivo: Comparar a camada de fibras nervosas da retina, a camada de células ganglionares, a camada plexiforme interna e a espessura coróide entre os pacientes com doença de Behçet e indivíduos saudáveis usando tomografia de coerência óptica (OCT) de domínio espectral (SD). Métodos: Noventa olhos de 45 indivíduos saudáveis e 104 olhos de 52 pacientes com doença de Behcet foram incluídos no estudo. O fator reumatoide e os níveis de proteína C-reativa foram medidos por exames de sangue em pacientes com doença de Behcet. Resultados: As médias de espessura da camada de fibras nervosas da retina, da camada de células ganglionares e da camada plexiforme interna dos pacientes com Doença de Behcet foram significativamente menores do que o grupo controle. As medidas de espessura coróide média dos pacientes com doença de Behcet foram significativamente mais elevadas do que o grupo controle. Conclusões: Tomografia de coerência óptica é uma ferramenta útil e não invasiva para acompanhar a degeneração nervosa retiniana e as alterações coroidais em pacientes com doença de Behcet, mesmo sem envolvimento ocular.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Behcet Syndrome/diagnostic imaging , Tomography, Optical Coherence , Retina/diagnostic imaging , Retinal Ganglion Cells/pathology , Rheumatoid Factor/blood , C-Reactive Protein/analysis , Case-Control Studies , Choroid/diagnostic imaging , Macula Lutea/diagnostic imaging , Nerve Fibers/pathology
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